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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations 8-OH-dg: 8-hydroxy-2-deoxyguanosine AM: airway macrophage BAL: bronchoalveolar lavage ELF: epithelial lining fluid GSH: glutathione (reduced form) GSSG: glutathione disulfide (oxidized form) HAT: histone acetyltransferase HDAC: histone deacetylase ICS: inhaled corticosteroid MDA: malondialdehyde PARP: poly (ADP-ribose) polymerase References Fitzpatrick AM, Gaston BM, Erzurum SC, Teague WG 2006 Features of severe asthma in school-age children: atopy and increased exhaled nitric oxide

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doi: 10.3389/fnagi.2024.1455858 Received 27 June 2024 Accepted 19 September 2024 Published 02 October 2024 Volume 16 - 2024 Edited by Kimberly Stieglitz, Roxbury Community College, United States Reviewed by Fawad Khan, Ochsner Health System, United States Faten Mohamed Ibrahim, National Research Centre, Egypt Updates Copyright 2024 Chen, Meng and Ko

The question isn't whether glutathione works in isolation